January 13, 2011

The New Coumadin Alternative…What Do Patients Think About It?

Posted in Heart disease tips, Helpful Heart Links, Uncategorized tagged , , , , , , , , , , at 11:47 am by keepyourhearthealthy

image by Idea go

Pradaxa is certainly ideal when you look at how it compares to Coumadin on paper.

Pradaxa is a breakthrough Coumadin alternative that prevents more strokes than Coumadin, does not require fingerstick monitoring and has almost no major interactions with food or other drugs. It sounds like a dream come true for atrial fibrillation patients everywhere who despise Coumadin!

Now that Pradaxa is readily available to patients, what do they think? Is it the amazing new drug that many have expected it to be?  Some say “yes” and some say “no.”  One Pradaxa user posted their experience with the drug on a Pacemaker Club website online and stated they “love the convenience.” Others on the same website complained that it did not work out for them.

The biggest obstacles for many are just what Pradaxa’s manufacturer expected: price and heartburn.  First, many people have to get over the sticker-shock of paying $40 to $250 per month.  Then there’s the common side effect of heartburn.  20% of patients discontinue Pradaxa because it upsets their stomach.

One patient I spoke to stopped it because the heartburn and nausea were intolerable after a few days of switching to Pradaxa.  She eventually switched back to Coumadin and resumed her routine INR checks.  In my opinion she was more likely to get heartburn on the Pradaxa because she also suffers from a large hiatal hernia (a condition where part of the stomach is squeezed up through the diaphragm) which causes problems with acid reflux.  Pradaxa’s manufacturer has already launched a defensive campaign in order to help patients work through problems related to the drug.  Their website www.pradaxa.com offers a support program which includes a hotline and a savings card.  I personally registered for the support program over 2 weeks ago and have yet to receive a response.  Maybe they have a few kinks to work out?

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September 2, 2010

New Alternative to Coumadin and Warfarin?

Posted in Heart disease tips, New Heart Studies tagged , , , , , , , , , , , , at 11:58 pm by keepyourhearthealthy

photo by Michal Marcol

Patients with atrial fibrillation know all too well the problems with Coumadin and warfarin.

Atrial fibrillation is a very common arrhythmia in which the top chambers of the heart beat quickly and erratically.  Since the pumping of the atria is abnormal during atrial fibrillation, a clot can form in the heart.  If the clot travels up to the brain this leads to a stroke.  For this reason, people with atrial fibrillation are at a higher risk of stroke and may need to take a strong blood thinner called Coumadin (generic name warfarin).

Coumadin and warfarin dosages are variable and need frequent monitoring.  One person may only need to take 5mg per day while another person might need 7.5mg per day.  Fingerstick checks are done every few days to every month for checking the level (called INR).  People who cannot or will not take Coumadin need to take at least an aspirin a day to lower the risk of stroke.  Sounds like a lot of work right?

A simpler drug may be available soon!  A new study out of Ontario has reviewed a new medicine called apixaban in terms of replacing Coumadin and warfarin.  When compared with aspirin only, apixaban reduced the risk of stroke and other clotting problems by 54%!  The dose is standard for everyone and apparently there is no need for fingerstick checks.  Let’s pray that apixaban makes it through the next trial so we can truly have a great new alternative to Coumadin!